Study: Gestational diabetes, prediabetes could increase breast cancer risk in African-American women
WASHINGTON — Researchers have found signaling pathways in cells that may allow earlier detection and prevention of cancer in African-American women.
According to a study presented at the American Association of Cancer Research’s Fourth AACR Conference on the Science of Cancer Health Disparities in Washington, while the pathways can be detected in cells that have not become cancerous, they also are linked to how cells consume and break down sugar, which raises concern that such conditions as gestational diabetes and prediabetes could stimulate precancerous cells and make them cancerous.
"We see a lot of very aggressive, triple-negative breast cancers among young African-American women and a very high death rate, with only 14% alive at five years," Duke University professor of medicine and study researcher Victoria Seewaldt said. "We wanted to figure out why this was occurring among these women."
Seewaldt and her colleagues looked at two independent groups of 39 and 38 premenopausal African-American women who were considered to be at high risk of cancer because they had mothers or sisters who died of breast cancer at an early age.
"We found that in a high proportion of high-risk African-American women, these precancerous cells were taking in a high amount of glucose, and they also had activation of insulin signaling," Seewaldt said. "In these women, we would worry that if they had developed gestational diabetes that the condition could really stimulate precancerous cells."
Seewaldt said that exercise, weight loss and the diabetes drug metformin provided opportunities for preventing aggressive breast cancer in African-American women.
"These are things where a community approach could really make a difference," she said.
Target puts final Canadian plans in motion
MINNEAPOLIS — Target’s entry into Canada is nearing completion, as the company on Friday finalized its real estate transaction with Zellers with the selection of 84 additional Zellers leases, bringing the total number of leases, including an initial group of 105 leases selected in May, to 189.
From this second group, Target has acquired the leasehold interests for 29 locations, the vast majority of which will open as Target stores beginning in 2013. The remaining leases have been or will be sold to other Canadian retailers or back to landlords.
Target’s venture into Canada began in January when the company announced that it had agreed to pay C$1.825 billion to purchase from Zellers, a subsidiary of the Hudson’s Bay Co., the leasehold interests in up to 220 sites currently operated by Zellers.
“Target is excited to take another meaningful step toward our expansion in Canada,” Target Canada president Tony Fisher said. “We look forward to delivering a superior shopping experience for our guests throughout Canada and building on our strong reputation as a good neighbor and partner in the communities in which we do business.”
Target said it plans to open 125 to 135 stores in Canada, the majority of which will open in 2013, beginning with the first cycle in March and continuing with four subsequent cycles later in the year. The company said it will invest about $10 to $11 million in remodeling each location. Locations for the March 2013 store openings will be revealed in the coming months, Target said, with subsequent opening cycles to be announced throughout 2012.
When Target’s Canada stores do open, they will face competition from a number of retailers, including Walmart, which ended last year with 325 stores and has plans to open 40 additional stores this year, bringing its total count by year’s end to roughly 333 stores. Walmart is in the midst of a U.S.-style supercenter conversion, so by the end of this year, roughly half of the company’s roughly 333 units will be supercenters; and by 2013, the total store count figure should be north of 350 with supercenters accounting for roughly two-thirds of the total, and that’s assuming expansion and conversion activity doesn’t accelerate from the current pace in anticipation of Target’s arrival.
Rockin’ Green debuts two new products at expo
SAN ANTONIO — Rockin’ Green has expanded its lineup of cleaning products with two new items.
The company debuted Melody, an odor neutralizer and air freshener room spray, and Groupies, the brand’s new dryer balls that are made with such natural materials as reclaimed potato starch, at the 2011 ABC Kids Expo. The products will make their retail debut in October.
"Rockin’ Green is committed to creating products that help make the laundry process easier and more eco-friendly. Our newest editions, Melody and Groupies, are no different in that they make the cleaning process more enjoyable, greener and more fun, at least I think so," Rockin’ Green founder and CEO Kimberly Webb said.
Melody is available in an 8 fl.-oz. pump spray bottle for a suggested retail price of $8.95, while Groupies are sold individually for a suggested retail price of $8.50.