World Health Organization announces flu pandemic alert change
GENEVA The current situation regarding the outbreak of swine influenza A(H1N1) is evolving rapidly, the World Health Organization stated in a press release Monday.
“As of 27 April, the United States government has reported 40 laboratory confirmed human cases of swine influenza A(H1N1), with no deaths. Mexico has reported 26 confirmed human cases of infection with the same virus, including seven deaths. Canada has reported six cases, with no deaths, while Spain has reported one case, with no deaths,” WHO stated.
In responose, WHO Director-General Margaret Chan has raised the level of influenza pandemic alert from the current phase 3 to phase 4. The change to a higher phase of pandemic alert indicates that the likelihood of a pandemic has increased, but not that a pandemic is inevitable.
In Phase 3, an animal or human-animal influenza reassortant virus has caused sporadic cases or small clusters of disease in people, but has not resulted in human-to-human transmission sufficient to sustain community-level outbreaks. Limited human-to-human transmission may occur under some circumstances, for example, when there is close contact between an infected person and an unprotected caregiver. However, limited transmission under such restricted circumstances does not indicate that the virus has gained the level of transmissibility among humans necessary to cause a pandemic.
Phase 4 is characterized by verified human-to-human transmission of an animal or human-animal influenza reassortant virus able to cause “community-level outbreaks.” The ability to cause sustained disease outbreaks in a community marks a significant upwards shift in the risk for a pandemic. Phase 4 indicates a significant increase in risk of a pandemic but does not necessarily mean that a pandemic is a forgone conclusion.
Phase 5 indicates an imminent pandemic and phase 6 signifies an actual pandemic.
New research may lead to understanding of sepsis, NEC in children
STANFORD, Calif. New research from Lucile Packard Children’s Hospital and the Stanford University School of Medicine is helping physicians unravel the cause of a deadly and mysterious bowel disease that strikes medically fragile newborn babies.
The findings could lead to a better understanding of the disease and its medical management, and also shed light on the causes of sepsis, a major killer of children and young adults.
The bowel disorder, necrotizing enterocolitis, or NEC, is seen mainly among premature infants, affecting about one-in-every 2,000 births. A similar constellation of symptoms, also labeled NEC, is also seen in children born with congenital heart defects. The disease causes intestinal inflammation and impairs nutrient uptake. Complications can include perforation of the intestine and widespread infection of the abdominal cavity or blood — sepsis — as well as lasting consequences such as the need for bowel transplant or chronic intravenous feeding.
The findings, which will appear in the May issue of the journal Pediatrics, suggest that the diagnosis of NEC in premature infants versus those with heart disease may actually encompass two distinct disease processes with different origins.
“If we start accepting that we are looking at two different diseases, further research may be able to elucidate some differences in the disease process and help us tailor management,” stated senior study author Sanjeev Dutta, assistant professor of surgery and pediatrics at Packard Children’s and the School of Medicine.
Right now, because physicians have such a poor understanding of what causes the disease, they can’t tell which infants will be hardest hit, Dutta said. “At present, we’re managing all cases the same way without addressing the concept that the child with heart disease may have a different underlying cause of NEC than the child with prematurity alone. We’re giving support, but not really curing the disease.”
To gain insight into how necrotizing enterocolitis starts, Dutta and his collaborators investigated whether a pre-existing medical problem—congenital heart defects—affected the course of the disease. They reviewed medical records from 76 infants who had a congenital heart defect together with necrotizing enterocolitis and 126 infants who had necrotizing enterocolitis alone. All study subjects were patients at Packard Children’s between May 1999 and August 2007.
The researchers found that babies who had both necrotizing enterocolitis and a congenital heart defect fared better than those who had necrotizing enterocolitis alone. Even premature babies with heart defects did better than those who were premature alone. Babies who had heart defects were less likely than other affected infants to suffer intestinal perforation or abnormal narrowing of the bowel. They also were less likely to need surgery to resolve infection, to require an artificial drain through the abdominal wall for managing bowel perforation or to require removal of portions of diseased intestine.
The findings suggest that infants with heart defects may be getting the disorder because of reduced blood flow to the bowel, while those with normal hearts may get the disease for other reasons, such as a bad reaction to oral feeding in premature infants with an underdeveloped gut. Both poor blood flow and gut immaturity have been blamed for NEC before, but the relative importance of each factor has been unclear.
Another possibility suggested by the researchers is that the close medical monitoring given to infants with heart defects helps physicians detect the intestinal problem early and thus institute therapy more quickly.
Although necrotizing enterocolitis is relatively rare, “it’s a disease that has a huge impact on society,” Dutta said. “These kids can get very sick and die, or suffer permanent injury to the bowel.”
Infants who survive often require repeat hospitalizations and expensive treatments throughout their lives.
Swine flu update: Cases confirmed at NYC prep school
NEW YORK As of 1 p.m. Monday, the Centers for Disease Control and Prevention confirmed 20 additional cases of swine flu in New York, bringing the total number of swine flu cases so far to 40 overall and 28 in New York.
The New York City Department of Health is investigating a cluster of illness at the St. Francis Preparatory School in Queens, where 100 students missed classes because of flu-like illness last week. Daily calls with hospitals and monitoring of admissions have yet to suggest a wider or more severe outbreak.
The 20 additional cases of swine flu were associated with the St. Francis Preparatory School, the CDC confirmed.
All of the patients suffered only minor illness.
The NYC Health Department has also identified 17 more probable cases within the St. Francis school cluster. Nasal swabs from those patients are undergoing confirmatory testing at the CDC.