Teva launches generic Exforge HCT tabs
BY Ryan Chavis
JERUSALEM — Teva Pharmaceutical on Monday announced the launch of a generic version of Exforge HCT (amlodipine, valsartan, hydrochlorothiazide) tablets in the United States. Teva was first to file for the generic, according to the company.
Exforge HCT tablets, which are marketed by Novartis, had annual sales in the United States of approximately $158 million as of September 2014, according to IMS Health data.
CDC: Only 30% of Americans with HIV have the virus under control
ATLANTA — Just 30% of Americans with HIV had the virus under control in 2011, and approximately two-thirds of those whose virus was out of control had been diagnosed but were no longer in care, according to a new Vital Signs report published Tuesday by the Centers for Disease Control and Prevention. The new study underscores the importance of making sure people with HIV receive ongoing care, treatment and other information and tools that help prevent transmission to others, as well as the need to reach more people with HIV testing.
Among those whose infection was not under control, more than three times the proportion (66%) were no longer in care as had never been diagnosed (20%).
The HIV epidemic continues to threaten the health and well-being of many Americans — with more than one million people living with the disease in the United States and 50,000 new infections each year.
When used consistently, antiretroviral medication can keep HIV controlled at very low levels in the body (known as viral suppression), allowing people with HIV to live longer, healthier lives and reducing the likelihood they will transmit HIV to others. Treatment has been shown to reduce sexual transmission of HIV by 96%, and U.S. clinical guidelines now recommend that everyone diagnosed with HIV receive treatment, regardless of their CD4 cell count or viral load.
"For people living with HIV, it’s not just about knowing you’re infected — it’s also about going to the doctor for medical care,” stated CDC director Tom Frieden. “And for healthcare facilities, it’s not just about the patients in your care — it’s every person diagnosed, and every person whose diagnosis has not yet been made. Key to controlling the nation’s HIV epidemic is helping people with HIV get connected to — and stay in —care and treatment, to suppress the virus, live longer and help protect others.”
The new study estimates that of the 1.2 million Americans living with HIV in 2011, 70% did not have their virus under control. Among the nearly 840,000 people who had not achieved viral suppression:
- 66% had been diagnosed but were not engaged in regular HIV care;
- 20% did not yet know they were infected;
- 4% were engaged in care but not prescribed antiretroviral treatment;and
- 10% were prescribed antiretroviral treatment but did not achieve viral suppression.
The percentage of Americans with HIV who achieved viral suppression remained roughly stable (26% in 2009 vs. 30% in 2011).
CDC has increased the focus on diagnosing people with HIV, supporting linkage to ongoing care and treatment, provision of risk reduction information, and increasing medication adherence. By making the most of these strategies for those who are HIV-positive, as well as other high impact strategies to protect those who remain uninfected but are at highest risk for HIV, CDC believes substantial progress can be made in reducing new infections.
“There is untapped potential to drive down the epidemic through improved testing and treatment, but we’re missing too many opportunities,” commented Jonathan Mermin, director of CDC’s National Center for HIV/AIDS, Viral Hepatitis, STD and Tuberculosis Prevention. "Treatment is crucial. It is one of our most important strategies for stopping new HIV infections."
Current initiatives to promote HIV testing and treatment include innovative partnerships to make HIV testing simple, accessible and routine; programs to help health departments identify and reach out to infected individuals who have fallen out of care; and public awareness campaigns to urge testing and encourage people with HIV to seek ongoing care.
These efforts are an essential component of the National HIV/AIDS Strategy, launched in 2010. Key goals of the strategy include reducing HIV incidence, increasing access to care and optimizing health outcomes, and reducing HIV-related health disparities.
Today’s study also found that viral suppression increased with age, with young people significantly less likely than older age groups to have their virus under control — only 13% of people ages 18 years to 24 years were virally suppressed, compared to 23% among those ages 25 years to 34 years, 27% among those ages 35 years to 44 years, 34% among those ages 45 years to 54 years, 36% among those ages 55 years to 64 years and 37% among those ages 65 years and older.The researchers attribute the disparity in large part to the fact that fewer than half (49%) of 18- to 24-year olds with HIV have been diagnosed, underscoring the need for more HIV testing in this population.
“It’s alarming that fewer than half of HIV-positive young adults know they are infected,” said Eugene McCray, director of CDC’s Division of HIV/AIDS Prevention. “Closing that gap could have a huge impact on controlling HIV — knowing your status is the first critical step toward taking care of your own health and avoiding transmission to others.”
The study did not find statistically significant differences in viral suppression by race or ethnicity, sex or risk group.
ACEP warns against overindulgence
WASHINGTON — The American College of Emergency Physicians on Tuesday warned against overindulgence through the holidays in an effort to raise awareness around diabetes.
"Diabetes causes patient complications that we see in emergency departments every day, such as heart disease, stroke, kidney failure and a variety of other problems," stated Michael Gerardi, president of the American College of Emergency Physicians. "With a good diet and exercise, most cases of type 2 diabetes can be prevented or reversed. If you know you have it and work closely with a doctor, you can control it."
More than 29 million Americans have diabetes, according to the CDC, which is more than 9% of the U.S. population. More than eight million of those people are undiagnosed, which is 1-out-of-4 Americans. According to the CDC, 15% to 30% of people with pre-diabetes will develop type 2 diabetes within five years.
"Decisions you make or choose not to make now will ultimately affect the rest of your life," Gerardi said. "Just by eating healthy and becoming more active, you can cut your risk of diabetes by half."
ACEP is a national medical specialty society representing emergency medicine. ACEP is committed to advancing emergency care through continuing education, research and public education.
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