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Study: Metformin use during adolescence may help girls delay, prevent PCOS

BY Allison Cerra

NEW YORK — A study slated to appear in the Journal of Clinical Endocrinology & Metabolism, a publication of the Endocrine Society, found that adolescent girls that take the diabetes drug metformin may prevent or delay the development of polycystic ovary syndrome, a common cause of infertility.

The study, led by Lourdes Ibáñez, professor of pediatrics at the University of Barcelona, noted that PCOS typically develops during adolescence and compared the efficacy of early versus late metformin treatment to prevent adolescent PCOS. Among 38 girls with low birth weight and early puberty, 19 of them that were 8 years of age were treated with daily doses of metformin for four years, while the other half of subjects began receiving daily doses of metformin at age 13 and continued treatment for just one year.

Researchers found that early metformin therapy prevented or delayed the development of hirsutism, androgen excess and PCOS more effectively than late metformin treatment. Ibáñez and colleagues said that excessive weight gain that occurs in adolescence may overexpose the ovaries to insulin, thus boosting the PCOS risk among female adolescents.

“Metformin, when given across the potentially critical window of puberty, may have the capacity to reprogram metabolism toward less abdominal and liver fat,” Ibáñez said. “In the years ahead, the focus of attention should shift from late treatment of PCOS and its complications, toward the early and large-scale prevention of PCOS, with measures such as diet, exercise and metformin in young girls.”

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New fitness DVD from Tracey Mallett launches

BY Allison Cerra

LOS ANGELES — A new workout DVD from fitness and lifestyle expert Tracey Mallett has hit retail.

New "Booty Barre Plus Abs & Arms" is an 80-minute fitness DVD that combines the toning benefits of yoga, pilates, ballet and dance to strengthen and stretch the body. In this DVD, Mallett shows viewers how to firm, tighten and tone their bodies, as well as streamline their arms and core muscles. Viewers will need a sturdy chair or ballet barre, in addition to a set of 3-lb. to 5-lb. dumbbells to get started.

"Booty Barre Plus Abs & Arms" will retail for $19.95.

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Redbox leader resigns

BY Allison Cerra

BELLEVUE, Wash. — Coinstar announced that the president of its DVD rental subsidiary has resigned.

Redbox president Mitch Lowe, who has led the business since April 2009 after joining the company in 2005, will leave to pursue other entrepreneurial interests. Lowe will stay on as president until a successor is named, Coinstar said, adding that the company has begun to search for a replacement.

"On behalf of Coinstar and the Redbox organization, I want to thank Mitch for his many contributions over the last eight years, particularly in establishing Redbox as a leader in the home entertainment business," Coinstar CEO Paul Davis said. "A true entrepreneur, we wish him the best as he pursues other passions. I am also excited for the future of the Redbox business, and, as such, we will be seeking a new leader to help us realize the next chapter in the Redbox growth story."

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