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Study: Aspirin not only prevents pain and inflammation, it also helps end inflammation

BY Michael Johnsen

SAN DIEGO — Researchers at the University of California, San Diego School of Medicine concluded that aspirin, in addition to preventing pain and inflammation, actually helps hasten the end of inflammation in a study published this week in the online early edition of PNAS.
 
Non-steroidal anti-inflammation drugs like aspirin, naproxen and ibuprofen all work by inhibiting or killing an enzyme called cyclooxygenase – a key catalyst in production of hormone-like lipid compounds called prostaglandins that are linked to a variety of ailments, from headaches and arthritis to menstrual cramps and wound sepsis.
 
But the San Diego School of Medicine researchers found that aspirin has a second effect: Not only does it kill cyclooxygenase, thus preventing production of the prostaglandins that cause inflammation and pain, it also prompts the enzyme to generate another compound that hastens the end of inflammation, returning the affected cells to homeostatic health.
 
“Aspirin causes the cyclooxygenase to make a small amount of a related product called 15-HETE,” stated senior author Edward Dennis, distinguished professor of Pharmacology, Chemistry and Biochemistry. “During infection and inflammation, the 15-HETE can be converted by a second enzyme into lipoxin, which is known to help reverse inflammation and cause its resolution – a good thing.”
 
Specifically, Dennis and colleagues looked at the function of a type of white blood cells called macrophages, a major player in the body’s immune response to injury and infection. They found that macrophages contain the biochemical tools to not just initiate inflammation, a natural part of the immune response, but also to promote recovery from inflammation by releasing 15-HETE and converting it into lipoxin as the inflammation progresses.
 
Dennis said the findings may open new possibilities for anti-inflammatory therapies by developing new drugs based on analogues of lipoxin and other related molecules that promote resolution of inflammation. “If we can find ways to promote more resolution of inflammation, we can promote health,” he said.

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Report: Plans for Giant Eagle’s Columbus, Ohio, Market District Express moving forward

BY Michael Johnsen

BEXLEY, Ohio — Giant Eagle is planning to open a Market District Express store in Columbus, Ohio, according to a report in The Columbus Dispatch published Tuesday. 
 
According to the report, the city's Planning Commission is reviewing plans for a two-story, 30,000-square-foot store. The location is expected to field a sushi bar, a pharmacy and a selection of wine and craft beer. 
 
In December, Giant Eagle opened its first Market District Express location near Pittsburgh. Giant Eagle has also targeted the Cleveland area for Market District Express expansion. 
 

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Wegmans LPGA Championship generates $1 million for United Way’s Children’s Success Fund

BY Michael Johnsen

ROCHESTER, N.Y. — At the conclusion of this year’s Wegmans LPGA Championship, Wegmans VP Bill Strassburg presented United Way’s Children’s Success Fund with a check for $1 million, more than double the amount donated to the charity for previous tournaments and an amount likely to exceed the final tally of proceeds from this year’s tournament.
 
“We are so proud to have been part of this world-class event,” stated Colleen Wegman, president. “We thank our people who worked so hard to make this possible, along with our partner suppliers, the volunteers and our entire community. They came together to make this a memorable and meaningful event for the youth in Rochester.”
 
All of the proceeds from the Wegmans LPGA Championship Tournament have been invested in the goal of helping kids to graduate from high school. United Way’s Graduation is the Goal supports evidence-based programs that show significant promise. The Fund helps to support programs like the Hillside Work Scholarship Connection that has been proven to double graduation rates, along with other programs that serve children who are at risk of dropping out.
 
Over the life of the Rochester LPGA tournament, more than $11 million has been donated to programs in the Rochester community that help children succeed.
 

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