PHARMACY

Rexam teams up with Marsh, MainStreet Market pharmacies to offer safe Rx disposal

BY Allison Cerra

PERRYSBURG, Ohio — Rexam Prescription Products recently partnered with Marsh and MainStreet Market pharmacies for a new campaign that encourages consumers to safely dispose of their unused or expired medications.

The "Clean Out Your Medicine Cabinet" campaign encouraged consumers could bring their leftover medications to one of 40 Marsh Pharmacy and MainStreet Market Pharmacy locations throughout Indiana for free and safe disposal. More than 37,000 vials were collected over a 4-day period and were properly disposed through a local incinerator. Marsh first began hosting "clean out" events in 2008, and since that time has collected more than 140,000 vials of unused medications.

"We are pleased to partner with Marsh and support their efforts to improve prescription disposal," said Pat O’Connell, Rexam’s VP sales and marketing for prescription products. “It’s another example of how we work closely with our customers to address industry issues and add value to consumers’ lives."

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PHARMACY

Lilly, BI diabetes drug shows greater A1C reduction in African-American adults than placebo, study shows

BY Alaric DeArment

RIDGEFIELD, Conn. — A drug used to treat Type 2 diabetes produced significant reduction in blood sugar in African-American patients, according to results of a late-stage clinical trial.

Boehringer Ingelheim Pharmaceuticals and Eli Lilly announced Thursday results of a phase-3 trial of Tradjenta (linagliptin) in which 226 patients with Type 2 diabetes received 5 mg of the drug once per day or placebo.

Patients in the treatment group showed a reduction of HbA1C of 0.88%, compared with 0.24% among those receiving placebo. The drug makers noted that African Americans and other ethnic minority groups "significantly" are underrepresented in clinical trials, and this was the first published trial of a DPP-4 inhibitor — the drug class to which Tradjenta belongs — specifically conducted in African-American adult patients. Diabetes disproportionately affects African-Americans, with non-Hispanic African-American adults having a risk of developing the disease 77% greater than non-Hispanic white adults, according to the Centers for Disease Control and Prevention.


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CVS study: Targeted interventions versus broad adherence education proves more effective

BY Antoinette Alexander

WOONSOCKET, R.I. — Adherence interventions targeted to nonadherent patients proved more effective in improving medication adherence when compared with broad interventions that cast a wide net to encompass all medication takers, according to new research sponsored by CVS Caremark.

According to the study, entitled "Targeting Cardiovascular Medication Adherence Interventions,” more than one-third of adherence interventions targeted to nonadherent patients resulted in improved medication adherence, compared with 18% of broad interventions.

The study was conducted by researchers at Harvard University, Brigham and Women’s Hospital and CVS Caremark and was published in the May/June issue of the Journal of the American Pharmacists Association.

“While medication nonadherence is widely recognized as a major public health issue that impacts patient health and contributes to rising healthcare costs, there has not been a clear consensus about how best to influence patient behavior and support appropriate medication use," said Sarah Cutrona, a former research associate at Brigham and Women’s Hospital. "These results suggest that broad interventions, which aim to prevent nonadherence by educating and motivating all patients, were the least effective. Without the benefit of identifying patients and their specific barriers to adherence, these types of interventions may be too general to motivate individual patients to change their medication taking behavior."

The researchers reviewed nearly 60 peer-reviewed articles about randomized controlled trials for three types of interventions to improve medication adherence for cardiovascular disease or diabetes. These interventions included: broad interventions targeting all patients, focused interventions targeting nonadherent patients and dynamic interventions initially administered to all patients but then targeted to nonadherent patients based on real-time adherence information. Results found that dynamic interventions (32%) and focused interventions (25%) were more likely to show impact on adherence as compared with broad interventions (18%).

"This study is part of our ongoing research collaboration with Harvard and Brigham and Women’s Hospital to better understand the factors that impact mediation adherence," said Troyen Brennan, EVP and chief medical officer of CVS Caremark, who heads the research initiative that conducted the study. "As a pharmacy innovation company, we believe these results can be useful in helping to develop and better target adherence interventions so they are relevant for the patient and enable them to make better choices about their medications and achieve positive health outcomes."

The researchers concluded that targeting patients who are nonadherent to their cardiovascular medications may lead to better adherence, but more research is needed to determine how best to identify and intervene with nonadherent patients. The accuracy, cost and reproducibility of methods for identifying target populations should be a central consideration in future studies, especially in an environment where resources are limited and healthcare professionals and payers need to identify the most cost-effective and impactful ways to intervene and affect positive behavior change.

To view the entire article, click here.


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