PHARMACY

Report: Diplomat Specialty Pharmacy could aid revival of Flint, Mich.

BY Alaric DeArment

NEW YORK — After decades of failed comeback initiatives following the exit of General Motors, it looks like Flint, Mich., may be poised for a revival, according to published reports.

In a slideshow presentation on its website titled “11 Comeback Cities for 2011,” Kiplinger magazine ranked Flint at No. 7, thanks in large part to Diplomat Specialty Pharmacy’s decision to move its headquarters to the city.

Diplomat completed its move to the former General Motors Great Lakes Technology Centre in January and plans to invest $12 million and hire new staff.

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Impax faces generic Oxycontin patent challenge

BY Allison Cerra

HAYWARD, Calif. — Another generic drug maker is seeking to market its version of a popular opioid painkiller.

Impax said it had filed applications with the Food and Drug Administration seeking approval for a generic version of Purdue Pharma’s Oxycontin (oxycodone) controlled-release tablets in the 10-, 15-, 20-, 30-, 40-, 60- and 80-mg strengths.

Purdue filed suit against Impax on April 8 in the U.S. District Courts for the Southern District of New York, seeking to prevent Impax from marketing its version before the expiration of Purdue’s patents.

According to Wolters Kluwer Health, aggregate U.S. sales of Oxycontin since launch were approximately $2.8 billion for the 12 months ended in January.

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Pfizer, Medivation ‘disappointed’ in phase-3 trial results for Dimebon

BY Alaric DeArment

NEW YORK — A drug originally developed by scientists in the Soviet Union to treat allergies and currently under investigation by Pfizer and Medivation did not yield significant results in a late-stage clinical trial of patients with Huntington disease, a disorder that leads to cognitive decline, the companies said Monday.

In the phase-3 “HORIZON” trial, Dimebon (latrepirdine) did not produce a statistically significant improvement in patients’ conditions, leading the companies to cancel the study, which had enrolled more than 400 patients. Another study, “CONCERT,” in patients with Alzheimer’s disease is ongoing.

“We are disappointed with the results of the HORIZON trial given the high unmet need in this patient population,” Medivation president and CEO David Hung said. “At this point, we will discontinue development of Dimebon in Huntington disease, including the ongoing open-label extension study.”

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