PHARMACY

Oramed in early stages of development of insulin capsule

BY Drew Buono

JERUSALEM Oramed Pharmaceuticals is working on a new type of insulin drug for patients with Type 2 diabetes, this time, though, the drug is in a capsule form. The new capsule copies the way the body naturally processes the insulin.

The capsule causes insulin to penetrate from the gastrointestinal tract onto the liver. The organ then regulates the intake of the hormone prior to passing it onto the circulatory system. This revolutionizes the way in which insulin is delivered to the body by enabling its passage in a more physiologically normal manner. Oramed’s oral insulin capsule may make it possible for hundreds of millions of diabetics worldwide to receive earlier treatment of insulin, which would allow them to better control their diabetes.

“A capsule option would be a first choice for diabetics if it was available and a best-case solution,” says Nadav Kidron, chief executive officer of Oramed. “Oral insulin delivery is an idea with huge potential not only for patients who dislike needles but, with the insulin market generating $25 billion per year in worldwide revenues, it represents an enormous opportunity for drug developers as well.”

Oramed recently completed its Phase 1A clinical trials, which successfully assessed both the safety/tolerability and indicated absorption properties of the oral insulin capsule.

keyboard_arrow_downCOMMENTS

Leave a Reply

No comments found

TRENDING STORIES

PHARMACY

Study shows infrared thermometer helps cut down on diabetic foot ulcers

BY Drew Buono

WASHINGTON A new study published last month in the American Journal of Medicine showed that a new infrared digital thermometer decreases the chance of a diabetic receiving a foot ulcer, according to published reports.

Foot ulcers each year strike 600,000 U.S. diabetics, who are slow to notice they even have a wound because diabetes has numbed their feet. Worse, foot ulcers are so slow healing and vulnerable to infection that they’re to blame for most of the roughly 80,000 amputations of toes, feet and lower legs that diabetics undergo each year.

Using the thermometer reduced the number of high-risk patients who got foot ulcers by nearly two-thirds, according to Armstrong who studied 225 diabetic veterans.

The thermometer works by measuring the difference in temperature around the foot, looking for hot spots that can signal inflammation, which correlates to tissue injury. Patients measure half a dozen spots on each foot. When the thermometer signals a hot spot, they put up their feet for a day or so until the temperature normalizes. Easing pressure before the skin cracks lets the body heal more easily than it can with a full-blown wound.

“Heat is one of the most sensitive things, one of the first things that happens when we begin to have tissue breakdown,” says Crystal Holmes, a University of Michigan podiatrist who has begun prescribing the thermometers.

The results of the study, which took place over 18 months, showed that 12.2 percent of patients who did standard foot checks got ulcers, compared to 4.7 percent of those who used the thermometers.

The thermometer, called the TempTouch and made by Xilas, is currently available by prescription only.

keyboard_arrow_downCOMMENTS

Leave a Reply

No comments found

TRENDING STORIES

PHARMACY

AstraZeneca to conduct comparison between Crestor and Lipitor

BY Drew Buono

LONDON AstraZeneca announced that it will conduct a clinical trial comparing its cholesterol-fighting drug Crestor with Pfizer’s cholesterol drug Lipitor, the world’s best selling drug, according to Reuters.

The new trial, called SATURN, would compare the drugs’ ability to reduce the progression, or induce regression, of atherosclerosis, the main cause of cardiovascular disease, following two years of treatment in patients with coronary artery disease. Crestor was recently approved by the Food and Drug Administration to fight atherosclerosis.

AstraZeneca said the first of around 1,300 patients in the SATURN trial would be enrolled later this month and the study was expected to complete in 2011.

Lipitor had sales of $12.9 billion, compared to Crestor’s $2 billion in 2006.

keyboard_arrow_downCOMMENTS

Leave a Reply

No comments found

TRENDING STORIES