FDA accepts application for opioid-induced constipation drug
TARRYTOWN, N.Y. — The Food and Drug Administration has accepted a regulatory approval application from Progenics Pharmaceuticals and Salix Pharmaceuticals seeking an additional approval for a pain drug.
The two drug makers announced Tuesday that the FDA had accepted their supplemental new drug application for Relistor (methylnaltrexone bromide), an injectable drug for treating opioid-induced constipation.
The drug originally was approved for treating patients taking opioids for cancer pain, but the companies are seeking approval for OIC in patients with pain not related to cancer. The FDA plans to make a decision on the drug by April 27, 2012.
Kroger hasn’t forgotten; grocer to commemorate 9/11 in stores through September
CINCINNATI — Kroger on Tuesday reported the company will coordinate a moment of silence across all 2,449 stores in its network on Sept. 11 to remember the victims and honor the heroes of the 9/11 tragedy.
"To commemorate the 10th anniversary of the 9/11 attacks, we will invite our customers and associates to join together in a moment of silent reflection in all of our supermarkets," stated Dave Dillon, chairman and CEO of Kroger. "We also heard from many associates that they wanted to recognize the heroes in their communities during this time of national remembrance. Many of our stores will also say ‘thank you’ to our everyday heroes — the men and women who keep our families, communities and stores safe — through a variety of activities this September."
For example, across some districts, Kroger is making arrangements to prepare and deliver lunches, food trays, sheet cakes or gift baskets to local first responders, including fire departments, police departments and paramedics. In other districts, customers will be able to write personal messages on oversized cards or posters displayed in stores thanking military and emergency services personnel for their service.
Kroger also will encourage associate donations to the USO, a nonprofit, congressionally chartered, private organization whose mission is to help boost morale across the U.S. Armed Forces.
Study: Genetic variants associated with Type 2 diabetes found among South Asians
LONDON — A new study has identified six new genetic variants associated with Type 2 diabetes among South Asians.
An international teams of researchers, led by Imperial College London, noted that genetic factors have been "widely considered to play a role in the increased risk of Type 2 diabetes," and elected to examine the DNA of 18,731 people originating from South Asia (India, Pakistan, Sri Lanka and Bangladesh) with Type 2 diabetes and 39,856 healthy controls. The genomes of the participants were analyzed to look for locations where variations were more common in those with diabetes. The results identified six positions where differences of a single letter in the genetic code were associated with Type 2 diabetes, suggesting that nearby genes have a role in the disease.
"Type 2 diabetes is more common in South Asian populations than any other ethnic group, but the reason for this increased risk is unclear," senior study author from the School of Public Health at Imperial College London John Chambers said. "Although lifestyle factors such as unhealthy diet, physical inactivity and obesity are important causes of diabetes in South Asians, these are only part of the explanation. Our study identifies six new genetic variants linked to Type 2 diabetes in South Asians. Our findings give important new insight into the genes underlying of diabetes in this population, which in the long term might lead to new treatments to prevent diabetes," Chambers said.
The research was published in Nature Genetics.