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Astellas Pharma introduces Astagraf XL for kidney-transplant patients

BY Alaric DeArment

NORTHBROOK, Ill. — Astellas Pharma has introduced a new drug for preventing the body from rejecting transplanted organs, the company said Thursday.

The drug maker announced the availability of Astagraf XL (tacrolimus) extended-release capsules in pharmacies. The drug is designed for use in kidney transplant patients with Genenetech’s CellCept (mycophenolate mofetil) and corticosteroids, with or without induction of Novartis’ Simulect (basiliximab).

"The availability of Astagraf XL marks a significant moment for the transplantation community, giving new adult kidney transplant recipients an additional option in their immunosuppressant care," Astellas Pharma US president James Robinson said. "Astellas has long been a leader in the field of transplant immunology, and we are proud to continue to advance care for transplant recipients."


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Sears Holdings’ losses mount in second quarter 2013

BY Alaric DeArment

HOFFMAN ESTATES, Ill. — Sears Holdings Corp.’s losses grew in second quarter 2013, while EBITDA fell despite growth in the company’s online business and loyalty program, the parent company of Kmart said Thursday.

The company, based in suburban Chicago, said its online business at Sears.com and Kmart.com grew by 20% compared with second quarter 2012, while members of the Shop Your Way loyalty program generated more than 65% of sales, compared with 55% during the same period last year. Chairman and CEO Eddie Lampert cited the figures as evidence of progress toward the company being a "member-centric" retailer.

"While the increase in Shop Your Way promotional activity and member redemptions resulted in a meaningful increase in our costs, it demonstrates that our members are deepening their engagement with our program, which will allow us to further accelerate our transformation," Lampert said. "At the same time, we recognize how important it is to improve the profitability of our company, and I am disappointed that we did not deliver a better result."

The company posted a loss of $194 million, compared with $132 million in second quarter 2012, on the back of sales of $8.9 billion, compared with $9.5 billion a year ago. Kmart posted sales of $3.17 billion, compared with $3.37 billion in second quarter 2012, as comps decreased by 1.5%, including a 2.1% decrease for Kmart and a 0.8% decrease for Sears; Kmart’s decline was the result in decreases in the pharmacy, grocery and household categories, among others. Adjusted EBITDA for the quarter was a negative $55 million, compared with a positive $116 million in second quarter 2012.


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CVS Caremark outlines efforts to help combat national Rx drug abuse epidemic

BY Antoinette Alexander

WOONSOCKET, R.I. — CVS Caremark is continuing its efforts to battle the national prescription drug abuse epidemic by tapping its database to identify and stop inappropriate prescribing of high-risk drugs and is working at the federal and state levels to implement policy changes to curb prescription drug abuse.

"Prescription drug abuse in this country is an epidemic, but it doesn’t have to be," stated Troyen Brennan, EVP and chief medical officer of CVS Caremark and co-author of the article, "Abusive Prescribing of Controlled Substances – A Pharmacy View."  

Brennan added, "CVS Caremark, one of the largest providers of prescription drugs, is committed to mitigating prescription drug abuse by advancing legislation, promoting technology and creating safer communities."

In a new effort, CVS Caremark identified problem prescribers by studying their volume and share of high-risk drugs versus other providers in the same specialty and geographic region, as well as the ages of patients and their payment methods. The program identified 42 prescribers who were then asked to provide additional information about their prescribing habits. Of these, only six identified legitimate reasons for their unusual prescribing practices, the company stated. As a result of the analysis and outreach, CVS Caremark suspended controlled substance dispensing through the company’s CVS/pharmacy locations and the CVS Caremark Mail Service pharmacies for prescriptions written by the other 36 providers.

"While this program is not a comprehensive solution to prescription drug abuse, it is an important first step that is in line with the ethical duty pharmacists have to ensure that a prescription for a controlled substance is appropriate," added Mitch Betses, SVP pharmacy services of CVS/pharmacy and a co-author. "We know there are many ways to fight prescription drug abuse and we are committed to continuing to identify solutions to stop the improper use of controlled substances."

Details of the program were published online first on the New England Journal of Medicine website at nejm.org.

The use of controlled substances has increased dramatically, with prescriptions for opioids jumping more than 300% between 1999 and 2010. Overdose deaths increased from 4,000 annually to 16,600 during the same period. Such overdoses are now the second leading cause of accidental death in the United States, and more than 2.4 million people were considered to be opioid abusers in 2010, CVS Caremark stated.

The NEJM article highlights the role pharmacies can play in helping to curb the national epidemic of prescription drug abuse. The authors also call on lawmakers and regulators at the state and federal levels to enact policy changes that mandate more transparency into controlled substance prescribing, such as mandatory use of electronic prescribing, and a national, uniform program for prescription drug monitoring.

CVS Caremark also is working at the federal and state levels to implement policy changes to curb prescription drug abuse, including:

  • Mandatory Electronic Prescribing for Controlled Substances:  The company is urging federal regulators to require e-prescribing for these classes of drugs to reduce "doctor shopping," drug diversion and fraudulent prescriptions;
  • Improved Prescription Drug Monitoring Programs:  These state-run databases are operating in 46 states to help providers and pharmacists identify patients at risk of overdose and drug abuse, but improvements are needed to encourage interoperability between different states and make PDMP data directly available to prescribers and dispensers; and
  • Proper Prescription Drug Disposal:  CVS Caremark is committed to working with the Drug Enforcement Administration and other federal and state officials on more innovative and effective ways to manage drug take-back initiatives.

In other activities to help curb prescription drug abuse, CVS Caremark supports the Medicine Abuse Project, a multi-year initiative of The Partnership at Drugfree.org with the goal of preventing a half million teenagers from abusing prescription medication by the year 2017. In addition, all CVS/pharmacy locations throughout the country participate in the Sharps Compliance Takeaway Environmental Return program, which provides customers with the ability to safely dispose of their unused, expired or unwanted drugs using affordable medication disposal envelopes. The postage-paid envelopes allow customers to mail their unwanted prescription and OTC medications through the U.S. Postal Service to a licensed, secure facility for safe destruction. Controlled substances cannot be disposed of using this program.


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