PHARMACY

Adherence among chronic disease patients can lead to big savings

BY Antoinette Alexander

WOONSOCKET, R.I. — Patients with one or more out of four chronic diseases studied who take their medications as prescribed may save the healthcare system as much as $7,800 per patient annually, according to findings of a new CVS Caremark study analyzing annual pharmacy and medical costs over a three-year period.

The study findings revealed robust reductions in emergency department visits and in-patient hospital days from medication adherence. By avoiding those costly events, there were substantial savings in overall healthcare costs. The study, "Medication Adherence Leads to Lower Health Care Use and Costs Despite Increased Drug Spending," was released today in the January issue of Health Affairs.

Company researchers analyzed pharmacy and medical claims data of 135,000 patients with congestive heart failure, diabetes, hypertension and dyslipidemia to determine the direct effect of adherence on costs, according to Troyen Brennan, EVP and chief medical officer of CVS Caremark and a study author.

"There have been many studies through the years that suggest adherence can save on healthcare costs, but the issue has not been central to healthcare cost discussions because those studies did not establish a causal link. We took the research further, and what we found is that although adherent patients spend more on medications — as much as $1,000 more annually — across the board, they spend significantly less for their overall healthcare costs," Brennan stated.

The annual per person savings for chronically ill patients who were adherent to medications, compared with those who were not, amounted to $7,823 for those with congestive heart failure, $3,756 for diabetes, $3,908 for hypertension and $1,258 for dyslipidemia or high cholesterol. Brennan said CVS Caremark plans to share the study with healthcare regulators and federal legislators as they consider policies to reduce healthcare costs.

The study population included patients in the CVS Caremark book of business with congestive heart failure (16,353), diabetes (42,080), hypertension (112,757) and dyslipidemia (53,401).

Among the disease-specific findings are:

  • People with congestive heart failure spent $39,076 on average annually and had an average of 11.9 days in the hospital. Those with congestive heart failure were older, averaging 77 years of age;

  • Diabetes costs per patient on average were $17,955 annually, and these patients had an average of 4.26 days in the hospital;

  • Hypertension patients spent $14,813 on average annually and had 3.29 days on average in the hospital; and

  • The annual spend for a person being treated for dyslipidemia was $12,688 on average. Hospital stays for these patients were 2.24 days on average.

Pharmacy costs for the patients ranged from $2,867 to $3,780 per year.

The researchers also found that adherence effects were more pronounced in elderly patients 65 years and older. They stated that changes in the recently passed health-reform law for Medicare, which reduced prescription costs for beneficiaries by eliminating the doughnut hole and providing for therapy management and wellness programs, "were prudent." They recommended policy analysts take a harder look at how adherence programs and incentives might bend the healthcare cost curve downward.

"No matter what the intervention, the researchers agreed that actively encouraging medication adherence for chronic disease should be a top priority," noted M. Christopher Roebuck, director of strategic research for CVS Caremark and lead author of the study. "Despite higher pharmacy spending, the reduction in hospitalizations and emergency room use resulted in substantial savings."

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PHARMACY

Genentech granted supplemental approval for Actemra

BY Alaric DeArment

SOUTH SAN FRANCISCO, Calif. — The Food and Drug Administration has expanded the approved usage of a drug made by Genentech, part of Swiss drug maker Roche.

The FDA approved Actemra (tocilizumab) for the inhibition and slowing of structural joint damage, improvement of physical function and achievement of clinical response in patients with moderate to severe rheumatoid arthritis. The drug originally was approved as a treatment for RA last year.

“This FDA approval further supports the efficacy of Actemra and follows a similar approval in the [European Union],” Genentech chief medical officer and head of global product development Hal Barron said. “For those who are faced with the daily challenges of RA, inhibition and slowing of joint damage is imperative if patients are to truly achieve their treatment goals.”

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PHARMACY

Spectrum, Viropro to develop biosimilar

BY Alaric DeArment

IRVINE, Calif. — A U.S. biotech company plans to develop a biosimilar of a monoclonal antibody used to treat cancers and autoimmune disorders.

Spectrum Pharmaceuticals announced Wednesday a deal with Viropro to develop a biosimilar rituximab, marketed under the brand name Rituxan by Roche’s Genentech division. Global sales of rituximab in 2009 were $5.6 billion, according to Spectrum.

“We are excited at the opportunity to develop our own proprietary biosimilar formulation of rituximab in anticipation of patent expirations for rituximab over the coming years,” Spectrum CEO Rajesh Shrotriya said.

The healthcare-reform bill, which President Barack Obama signed into law in 2010, created a regulatory approval pathway for biosimilars, also known as follow-on biologics, and some analysts expected the Food and Drug Administration to have draft regulations written by the end of this year, though it may take a few years before final regulations appear.

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