E-prescribing owes a debt of gratitude to meaningful use. Without the Office of the National Coordinator’s inclusion of the capability as a core measure, enabling physician technologies may not have taken off with such vigor. But where MU’s e-prescribing requirements — such as two-way transmissions, complete active medication lists and formulary information — leave off, real innovation — characterized by real-time transactions, automated requests and responses, and Intelligent Routing like Emdeon provides — begins with many valuable benefits for providers, pharmacies and patients.