A study published Monday online by JAMA may skew the conversation over multivitamin use negative, despite the fact that study authors maintain the study cannot be generalized across the general population given the study's subjects — namely, practicing physicians.

While headlines in the past two weeks warned consumers that calcium supplementation could increase the risk of cardiovascular disease, authors of the study that prompted those headlines — published last month in the peer-reviewed journal Heart — identified four significant confounding factors in the design of the study.