Study: Vitamin D deficiency associated with higher rates of heart disease, cancer

NEW YORK — A vitamin D boost may prevent early death from heart disease and cancer, according to a large scale study by Mount Sinai and a consortium of international collaborators, published online in the June issue of BMJ and released Monday. Analysis of pooled data by Paolo Boffetta, director of the Institute for Translational Epidemiology and associate director for Population Sciences of the Tisch Cancer Institute at Mount Sinai, and collaborators showed a strong association between low vitamin D levels and risk of death in general death from cardiovascular diseases and in death from cancer, at least in older people with a history of cancer.
“Going into our study, the effect of vitamin D supplementation on risk of death was not clear,” Boffetta said. “Our analysis confirms the protective nature of this substance especially in elderly patients.”
Deficiency is most common in the elderly, who get less sun. Limited understanding of just how much vitamin D is needed to achieve protection has meant a lack of consistent recommendations on supplementation, and the verdict is still out. The current study results argue that those deficient in vitamin D are more likely to die before those who are not, Boffetta reported.
Researchers analyzed data from eight European and American studies that included 26,018 men and women ages 50 years to 79 years. Followup analysis showed that 6,695 study participants died during the studies, including 2,624 from cardiovascular diseases and 2,227 from cancer. Comparison of the lowest and the highest levels of vitamin D in the deceased showed those with the lowest concentrations had a pooled risk ratio of 1.57, or nearly double the risk of overall death as those with high concentrations. Risk ratios for cardiovascular and cancer deaths in those with cancer history were similar. Despite varying levels of Vitamin D between country, sex and season of blood draw, the association between low levels of vitamin D and death was consistent.
“Vitamin D’s protective effect is clear,” Boffetta said. “If our results are confirmed in additional studies, it could lead to recommendations for greater vitamin D supplementation in foods, and to a better understanding of its role in cancer prognosis.”
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