CHICAGO — Medication to treat high blood pressure in older patients appears to be associated with an increased risk for serious injury from falling such as a hip fracture or head injury, especially in older patients who have been injured in previous falls, the JAMA Network Journals reported Monday.
Most people older than 70 years have high blood pressure, and blood pressure control is key to reducing risk for myocardial infarction and stroke. Previous research has suggested that blood pressure medications may increase risk of falls and fall injuries.
Researchers examined the association between BP medication use and experiencing a serious injury from a fall in 4,961 patients older than 70 years with hypertension. Among the patients, 14.1% took no antihypertensive medications, 54.6% had moderate exposure to BP medications and 31.3% had high exposure.
During a three-year follow-up, 446 patients (9%) experienced serious injuries from falls. The risk for serious injuries from falls was higher for patients who used antihypertensive medication than for nonusers and even higher for patients who had had a previous fall injury.
"Although cause and effect cannot be established in this observational study and we cannot exclude confounding, antihypertensive medications seemed to be associated with an increased risk of serious fall injury compared with no antihypertensive use in this nationally representative cohort of older adults, particularly among participants with a previous fall injury," wrote Mary Tinetti of the Yale School of Medicine. "The potential harms vs. benefits of antihypertensive medications should be weighed in deciding whether to continue antihypertensives in older adults with multiple chronic conditions."